BROCHURE
Dr. Srinath Pashikanti is a Assistant Professor,Idaho State University,USA

Dr. Srinath Pashikanti

Assistant Professor

Organizing Committee

USA

Idaho State University

BIOGRAPHY

Dr. Pashikanti has an MS degree in Chemistry & Biochemistry from South Dakota State University, an MS and Ph.D. in Medicinal Chemistry from The University of Kansas. Pashikanti Lab utilizes organic chemistry towards synthesis of cell permeable medicinally active analogs. He is an assistant professor in the Biomedical and Pharmaceutical Sciences Department, College of Pharmacy - Kasiska Division of Health Sciences, Idaho State University. He is actively involved in mentoring graduate and professional pharmacy students. His didactics include Principles of Drug Design and Drug Action, Physicochemical Basis of Drug Action, Principles of Biopharmaceutical Analysis, Advanced Organic Synthesis, Dissertation Research, Thesis Research, Independent Problems in Pharmaceutical Sciences, Pharmaceutical Science Research.

PUBLICATIONS

1. Cervantes, D.L., Pashikanti, S. Rutin derivatives as potent AGE inhibitors and its relevance in diabetes complications, FASEB J. 2007 21:646.1 2. Pashikanti, S., de Alba, D.R., Boissonneault, G.A., Cervantes, D.L. Rutin Metabolites : Novel Inhibitors of Non-oxidative Advanced Glycation End Products, Free Radical Biology and Medicine 2010; 48, 656 3. Pashikanti, S., Boissonneault, G.A., Cervantes, D.L. Ex vivo detection of histone H1 modified with advanced glycation end products, Free Radical Biology and Medicine 2011; 50, 1410 – 1416 4. Foster, A., Li, Y., Runyan, S., Dinh, T., Venadas, S., Chen, J., Pashikanti, S., Datta, A., Ehring, G., Staubli, U; Activity of the enantiomers of erythro-3-hydroxyaspartate at glutamate transporters and NMDA receptors, Journal of Neurochemisry 2016; 136, 692 – 697 5. Pashikanti, S., Ukani, R., David, S.L., Dutta, A. Total Synthesis and Structure-Activity Relationship Studies of the Cytotoxic Anhydrophytosphingosine Jaspine B (Pachastrissamine)" Synthesis 2017, 49, 2089-2100. 6. Pashikanti, S., Sibley, C.; Nguyen, M. K.; Santos, W.L.; Regio- and Stereoselective Copper (II)-Catalyzed Hydrosilylation of Activated Allenes in Water: Access to Vinylsilanes Organic Letters 2016; 18, 2443-2446 7. Pashikanti, S., Sibley, C.; Nguyen, M. K.; Santos, W.L.; Copper (II)-Catalyzed (E)-Selective Hydrosilylation of Allenes Synfacts 2016; 12, 0836-0836 8. Pashikanti, S., Afrin, F., Meldrum, T., Stegelmeier, J., Pavek, A., Habashi, Y., Fatema, K., Barrott, J. Quantifying fluorescently labeled ceramide levels in human sarcoma cell lines in response to a sphingomyelin synthase inhibitor. 2019, Methods and Protocols 2 (3), 76. 9. Tao, A., Huang, Y., Shinohara, Y., Caylor, M. L., Pashikanti, S., Xu, D. ezCADD: A Rapid 2D/3D Visualization-Enabled Web Modeling Environment for Democratizing Computer-Aided Drug Design. 2018, J.Chem. Inf. Model. 59 (1), 18-24. 10. Awale P, Lai JCK, Pashikanti S & Bhushan A.; Valproate-Induced Rodent Model of Autism Spectrum Disorder (ASD): Immunogenic Effects and Role of Microglia. Biopharmaceuticals and Nanomedicine, 3, Chapter 24 Pan Stanford Series on Clinical Nanomedicine, 2018.

EDUCATION

June 2014 The University of Kansas, Lawrence, KS Ph.D. Medicinal Chemistry, School of Pharmacy – KU Dec 2011 The University of Kansas, Lawrence, KS. M.S. Medicinal Chemistry, School of Pharmacy – KU Dec 2007 M.S. Chemistry & Biochemistry, South Dakota State University, Brookings, SD

RESEARCH INTEREST

Our current efforts are aimed to develop, synthesize and screen small molecules in targeting ceramide metabolizing enzymes. Ceramide is a bioactive sphingolipid that exhibits anticancer properties in cancer cells. Strategies aimed at increasing the cellular ceramide induce apoptosis in cancer cells. To complement our synthetic efforts, we utilize tools for protein biochemistry to perform in vitro experiments and cell-based assays in determining the biological activity of these analogs in a structure-activity relationship model.

HONORS AND AWARDS

2013 Graduate Scholarly Presentation Travel Award, The University of Kansas. 2010 – ‘13 Graduate Teaching Assistantship, School of Pharmacy & Chemistry Department, The University of Kansas. 2009 Graduate Research Assistantship, School of Pharmacy, The University of Jan – May Kansas. 2008 Graduate Research Assistantship, Biophotonics Lab, South Dakota State University, SD. (PI : Dr. Youngjae You). 2007 Graduate Travel Award, Department of Chemistry & Biochemistry, South Dakota State University. 2005 – ’07 Graduate Student Teaching Assistantship, South Dakota State University. 2005 Excellent Employee Awardee, Medicinal Chemistry Laboratory, GVK Biosciences, India (Number of employees ~ 300) 2004 Intellectual Property Right Quiz Competition, Andhra Pradesh Technology Development & Promotion Center, India. 2002 Lecturership Awardee, Council for Scientific and Industrial Research, University Grants Commission, India.

COLLABORATIONS

Sphingolipids Biological Relevance

EDITORSHIP

2014 – present Editorial Board Member, Cogent Chemistry (Open access) 2015 – present Editorial Board Member, Journal of Medicinal Chemistry (Open access)

Upcoming Conferences